ICSS Utility

Summary

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• Software controls:
  • Pulse amplitude
  • Pulse duration
  • Delay duration
  • Frequency
  • Train duration
• This source code may be used as is, or modified by the user to meet specific research demands

 

Core Procedures

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REWARD.mpc*

• ICSS threshold measurement
• Five trial blocks are presented in descending order until the animal meets an established criteria followed by five trial blocks in ascending order. The default number of columns run in this manner is four, contingent and non-contingent stimulations are equal.
• NOTE: Written originally for Dr. Conan Kornetsky, Boston University, School of Medicine.

DETECTION.mpc*

• Holds the rewarding or response-contingent stimulation constant.
  • *Kornetsky, Conan and Bain, George, Modern Methods in Pharmacology, Vol. 6, Testing and Evaluation of Drugs of Abuse, Brain-Stimulation
• Reward: A Model for Drug-Induced Euphoria, pp. 211–231.

 

Variant Procedures

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1. Stepwise titration of frequency

• Similar to the FR1 schedule described by J.L. Moreau1 (et al)
• Holds current constant while frequency steps from 70 Hz to 30 Hz and back again in 10 Hz steps every two minutes. 
  • 1 J.L. Moreau, F. Jenck, J.R. Martin, P. Mortas and W.E. Haefely, European Neuropsychopharmacology, 2, (1992), pp. 43–49

2. Autotitration of current

• Similar to what was described by Mumford2 (et al)
• Holds frequency constant
• This procedure requires two active levers. Starting current is set individually for each animal. One lever delivers stimulation that decreases 3 μA following every fifth reinforcement. The second lever resets the amplitude value back to the original starting current.
  • 2 Geoffrey K. Mumford, Darryl B. Neill, and Stephen G. Holtzman, Brain Research, 459 (1988), pp. 163–167

 

SKU:   SOF-700RA-5