Gastrointestinal Motility Monitoring

Gastrointestinal Motility Monitor (GIMM)

GIMM is a complete software/hardware package that is the result of research & development efforts aimed at making a powerful and easy-to-use setup for in-vitro measurements of motility patterns (such as the peristaltic reflex) and creating spatio-temporal maps in isolated segments of a laboratory animals’ gastrointestinal tract.

GIMM also enables accurate quantification of GI motility patterns in an experimental setting under resting conditions or with the presence of pharmacological test compounds.

It can also be used in the pharmacological evaluation of the effects of receptor agonists and antagonists on propulsive motility, and even patho-physiological conditions such as inflammation or stress.

Compared with traditional methods of monitoring colonic peristalsis, the GIMM system allows for continuous and quantitative evaluation of motility.

Example applications
> Monitor fecal pellet propulsion in distal colon
> Examining motility patterns in various gut regions using spatio-temporal mapping

 

GIMM SYSTEM FEATURES

• State-of-the-art recording of the peristaltic reflex in laboratory species (e.g. guinea pig) distal colon using fecal pellet propulsion assay as well as general motor patterns in small or large intestine using spatio-temporal mapping (motor maps).
• Versatile import/export capability, raw data can be ported into any spreadsheet program for graphing & analysis.
• The motor analysis screen is used to generate spatio-temporal maps, which can be saved and analyzed using the included “Image J” plugin.
• The easy-to-use computer interface makes organizing experimental data simple, using project files for each experiment which include identifying information (e.g. trial number, group title).
• Ideal for tracking fecal pellet propulsion in guinea pig distal colon. The analysis screen provides a cumulative record of velocity (distance x time) during video playback.